HIF1α Elevations at Tissue and Serum Levels and Their Association With Metabolic Disorders in Children With Obesity
Authors' conclusion
HIF1α expression is higher in the adipose tissue, especially omental, of children with obesity than in children with normal weight. Elevated serum HIF1α level is associated with adiposity and metabolic disorder, which may predict a higher risk of obesity complications.
Study context
- Population
- Children; paired subcutaneous and omental adipose tissue from 17 children, serum from the remaining children17 with adipose tissue
- Participants
- 519 children
- Exposure
- OV/OB children vs normal-weight children
- Outcome
- Adipose tissue HIF1α mRNA and protein expression and serum HIF1α level, and relationships with metabolic disorders
Main finding
As reported in the abstract
HIF1α levels
- Serum HIF1α positively correlated with BMI z-score, fat mass %, waist to height ratio, systolic BP, ALT, TG, uric acid and HOMA-IR
- In binary logistic regression, risks of insulin resistance (IR), nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome with serum HIF1α remained significant after adjustment for all potential confounders
- OV/OB vs Normal weight: P < 0.05
- OV/OB vs Normal weight: P < 0.05
Observational data: associations, not effects.
Further findings
Diagnostic performance of serum HIF1α
- AUC for IR
- 0.698 (95% CI 0.646-0.750; P < .001)
- AUC for NAFLD
- 0.679 (95% CI 0.628-0.731; P < .001)
- AUC for metabolic syndrome
- 0.900 (95% CI 0.856-0.945; P < .001)
Original publication
HIF1α Elevations at Tissue and Serum Levels and Their Association With Metabolic Disorders in Children With Obesity. J Clin Endocrinol Metab. Published 5 December 2023. doi:10.
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