Improved walking energy efficiency might persist in presence of simulated full weight regain after multidisciplinary weight loss in adolescents with obesity: the POWELL study
Authors' conclusion
Adolescents with obesity might not show an entire rise back to pre-weight loss values of their metabolic cost of walking when weight gain is simulated. These new findings suggest metabolic and physiological adaptations to weight loss of the energy metabolism that remain to be clarified.
Study context
- Population
- Adolescents with obesity (11 girls; 13.8 ± 1.4 y)
- Participants
- 21 adolescents
- Comparison
- Post-weight-loss walking without weight reload (V2) vs with reload equal to total weight lost (V2L) vs pre-weight loss (V1)
- Primary endpoint
- Energy cost of walking (Cw) during graded walking exercise (4×6-min at 0.75, 1, 1.25, 1.5 m.s-1)
Methodological details12-week multidisciplinary weight-loss intervention, randomised order of post-weight-loss conditions
- 12-week multidisciplinary weight-loss intervention
- Randomised order of post-weight-loss conditions
Primary result
As reported in the abstract
Cw
- V1 vs V2: absolute gross cost of walking (Cw) (ml.m-1) higher on V1 at every speed
- V1 vs V2L: P = 0.04
- V1 vs V2L: P = 0.02
- V2L vs V2: P = 0.03
- V1 vs V2: P < 0.001
- V2L vs V2: P = 0.006
Further findings
| Outcome | P value |
|---|---|
| Absolute fat utilizationV1 vs V2 · higher on V1 vs V2 and V2L | P < 0.001 |
| Absolute fat utilizationV1 vs V2L · higher on V1 vs V2 and V2L | P < 0.001 |
| CHO oxidation relative to body weightV1 vs V2 · lower on V1 | P = 0.04 |
| CHO oxidation relative to body weightV1 vs V2L · lower on V1 | P = 0.004 |
| Fat oxidation relative to body weightV1 vs V2 · higher on V1 | P = 0.002 |
Body composition after 12-week intervention
- Body weight and fat mass decreased
- P < 0.001
- FFM did not change
Absolute CHO oxidation (mg.min-1)
- No condition effect
- P = 0.12
Original publication
Improved walking energy efficiency might persist in presence of simulated full weight regain after multidisciplinary weight loss in adolescents with obesity: the POWELL study. Int J Obes (Lond). Published 5 December 2023. doi:10.
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