Obesity

Effects of light‐intensity physical activity on cardiometabolic parameters in young adults with overweight and obesity: The SED ‐ ACT randomized controlled crossover trial

Diabetes Obes MetabPublished Randomised controlled crossover trial

Authors' conclusion

Replacement and interruption of prolonged sitting with light-intensity walking showed a significant blood glucose-lowering effect and improved HRV during an 8-h work environment in young adults with overweight and obesity.

Study context

Population
Young adults with overweight and obesity; 8 women, mean age 23.4 ± 3.3 years, BMI 29.7 ± 3.8 kg/m², HbA1c 34.8 ± 3.1 mmol/mol [5.4 ± 0.3%]completed all four arms
Participants
17 adults
Comparison
Alternate sitting and standing, continuous standing or continuous walking vs uninterrupted prolonged sitting during an 8-h simulated workday
Primary endpoint
Mean 8-h glucose
Follow-up
8 h
Methodological detailsfour-arm
  • Four-arm

Primary result

As reported in the abstract

8-h mean glucose

P = 0.034

8-h mean glucose lower in all other conditions vs sitting (SIT)
P < 0.05

Secondary outcomes

OutcomeEstimateP value
2-h postprandial glucose after breakfastWALK vs SIT · lower with WALK≈7%P = 0.002

Heart rate variability (HRV) parameters

Significant time × condition effects on HRV parameters favouring light-intensity walking
P < 0.001

Original publication

Effects of light‐intensity physical activity on cardiometabolic parameters in young adults with overweight and obesity: The SED ‐ ACT randomized controlled crossover trial. Diabetes Obes Metab. Published 25 June 2024. doi:10.1111/dom.15732

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