Conversions between metabolically unhealthy and healthy obesity from midlife to late-life
Authors' conclusion
Conversions between metabolically healthy and unhealthy status occurred in both directions in all BMI categories. While conversions to MetS were more common among individuals with obesity, many individuals maintained or regained metabolic health during follow-up.
Study context
- Population
- Swedish twins followed from midlife to late-life (up to 27 years); metabolic health = absence of metabolic syndrome (MetS)
- Participants
- 786 Swedish twins
- Exposure
- Conversion in metabolic health status by body mass index (BMI) category
- Outcome
- Conversion between metabolically healthy and unhealthy (MetS) status by BMI category
- Follow-up
- Up to 27 years
Methodological detailstwin cohort, Cox proportional hazards regression
- Twin cohort
- Cox proportional hazards regression
Main finding
As reported in the abstract
Conversion to MetS among those metabolically healthy at baseline · during follow-up
Metabolically healthy at baseline who converted to MetS
59%
Conversions more often with metabolically healthy obesity vs normal weight
56%
Observational data: associations, not effects.
Further findings
Regaining metabolic health among those with MetS at baseline · during follow-up
- Regained metabolic health
- 60%
- No difference between BMI categories
BMI-metabolic health phenotypes across ages 50-64, 65-79 and ≥80
- Maintained metabolically healthy overweight or obesity across all three age categories
- one-fifth
- Proportion with MetS and with overweight or obesity increased with age
- Subsample of 100 individuals
Original publication
Conversions between metabolically unhealthy and healthy obesity from midlife to late-life. Int J Obes (Lond). Published 2 December 2023. doi:10.
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