Hemoglobin Levels Improve Fracture Risk Prediction in Addition to FRAX Clinical Risk Factors and Bone Mineral Density
Main finding · Major osteoporotic fracture (MOF)Result — go to the resultHazard ratio 2.04 95% CI 1.58–2.64Authors' conclusion
Anemia and decreasing levels of Hb are associated with lower cortical BMD and incident fracture in older women. Considering Hb levels may improve the clinical evaluation of patients with osteoporosis and the assessment of fracture risk.
Study context
- Population
- Community-dwelling women aged 75–80 years, Sweden
- Participants
- 2,778 women
- Exposure
- Anemia/low hemoglobin (Hb) vs no anemia/higher Hb
- Outcome
- Major osteoporotic fracture (MOF)
- Follow-up
- Median 6.4 years
Main finding
As reported in the abstract
Hazard ratio
2.04
95% CI 1.58–2.64
Anemiavs No anemia
HR 2.04 (95% CI 1.58–2.64)
Observational data: associations, not effects.
Further findings
Hip fracture and any fracture
- Similar results for hip fracture and any fracture, also when adjusting for clinical risk factors (CRFs)
Bone mineral density (BMD) · baseline
- Low Hb associated with worse total hip and femoral neck BMD, and lower tibia cortical and total volumetric BMD
Ratio of 10-year major osteoporotic fracture (MOF) probabilities, models with vs without Hb
- Ratio at 10th and 90th percentile of Hb, respectively
- 1.2 to 0.7
Original publication
Hemoglobin Levels Improve Fracture Risk Prediction in Addition to FRAX Clinical Risk Factors and Bone Mineral Density. J Clin Endocrinol Metab. Published 5 July 2023. doi:10.
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