Headache in pituitary adenomas: frequency, characteristics and outcome after treatment
Authors' conclusion
Migraine and tension-type are the most common headache phenotypes in PA patients, and TACs were only observed in prolactinomas. Also, headache was more common in prolactinomas than in NFPA. GH levels were higher in patients with acromegaly that presented headache. Surgical and medical treatments completely resolve the headaches in 50% of the patients.
Study context
- Population
- Treatment-naïve adults with pituitary adenoma (PA)
- Participants
- 104 adults
- Outcome
- Prevalence of headache
- Follow-up
- Previous 3 months
Main finding
As reported in the abstract
Headache prevalence
Headache present
62%
Observational data: associations, not effects.
Further findings
Headache by sex
- Headache in females
- 64%
- Headache in males
- 58%
- Similar rates
Age, with vs without headache
- Patients with headache younger: age (years), with vs without headache
- 41.5 ± 13.8 vs. 56.8 ± 13.6
Headache by tumour type
- Headache in prolactinomas
- 83%
- Headache in NFPA
- 52%
- Tumor characteristics not determinant of headache
- Acromegaly patients with headache had higher GH levels
Resolution of headache after disease remission or control · ≥3–6 months after treatment
- NFPA
- 83%
- Somatotropinomas
- 50%
- Prolactinomas
- 33%
Original publication
Headache in pituitary adenomas: frequency, characteristics and outcome after treatment. Pituitary. Published 9 February 2025. doi:10.
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