Descriptive analysis and outcomes of pituitary neuroendocrine tumours (PitNETs) treated surgically during pregnancy and postpartum
Authors' conclusion
PitNETs requiring surgical treatment during pregnancy are characterized by increased proliferative activity and progression after surgery. Despite this, the long-term prognosis remains favourable.
Study context
- Population
- Women with PitNETs treated surgically, 5 university hospitals
- Participants
- 10 vs 30
- Exposure
- PitNETs treated surgically during pregnancy/postpartum vs matched non-pregnant controls
- Pregnantn = 10
- Non-pregnant controlsn = 30reference
- Outcome
- Clinical, histological profiles and progression-free survival without additional treatment
Methodological detailsmulticentre, observational, matched controls
- Multicentre
- Observational
- Matched controls
Main finding
As reported in the abstract
- Pregnant vs Non-pregnant controls: P = 0.038
- Pregnant vs Non-pregnant controls: P = 0.049
- Pregnant vs Non-pregnant controls: P = 0.005
Observational data: associations, not effects.
Further findings
| Outcome | Pregnant | Non-pregnant controls | P value |
|---|---|---|---|
| Primary surgical indication: tumour syndrome ± failure of medical treatmentSimilar | 7/10 | 19/30 | P = 1.00 |
- Tumour volume and radiological invasion · volume; no significant difference
- P = 0.072
- Tumour volume and radiological invasion · optic chiasm compression; no significant difference
- P = 0.059
- Tumour volume and radiological invasion · cavernous sinus invasion; no significant difference
- P = 0.274
PitNET type (pregnant)
- Corticotropic
- 4
- Gonadotropic
- 2
- Lactotropic
- 2
- Somatotropic
- 2
Original publication
Descriptive analysis and outcomes of PitNETs treated surgically during pregnancy and postpartum. Eur J Endocrinol. Published 8 February 2025. doi:10.
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