Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity
Authors' conclusion
Habitual coffee or caffeine intake, especially at a moderate level, was associated with a lower risk of new-onset CM and could play important roles in almost all transition phases of CM development. Future studies are warranted to validate the implicated metabolic biomarkers underlying the relation between coffee, tea, and caffeine intake and CM.
Study context
- Population
- UK Biobank participants free of any cardiometabolic diseases at baseline172,315 caffeine
- Exposure
- Coffee, tea and caffeine intake levels vs nonconsumers or <100 mg caffeine/d
- Outcome
- New-onset cardiometabolic multimorbidity (CM): coexistence of ≥2 of T2D, coronary heart disease and stroke
Methodological detailsUK Biobank, multistate models
- UK Biobank
- Multistate models
Main finding
As reported in the abstract
New-onset CM
Each group vs nonconsumers or <100 mg caffeine/dHazard ratio (95% CI)
Moderate coffee
0.519(0.417–0.647)
Moderate caffeine
0.593(0.499–0.704)
Observational data: associations, not effects.
Further findings
Transitions between developmental stages of cardiometabolic multimorbidity (CM) (multistate models)
- Moderate coffee or caffeine intake inversely associated with risks of almost all developmental stages of CM, from disease-free to single cardiometabolic disease and subsequently to CM
Metabolites associated with both intake and incident CM
- Metabolites identified (e.g. VLDL lipid components, histidine, glycoprotein acetyls), of 168 measured among 88 204 and 96 393 participants
- 80 to 97
Original publication
Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity. J Clin Endocrinol Metab. Published 17 September 2024. doi:10.
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