Gut microbiota and microbial metabolites are associated with body composition in 5‐year‐old children: A cross‐sectional study in the Gen3G cohort
Authors' conclusion
In 5-year-old children, gut microbiota alpha diversity, richness and specific gut microbes were associated with OM, FM and LSTM. Many of the associations followed a similar pattern for FM and LSTM, suggesting they may not be specific to adiposity but rather reflect overall growth.
Study context
- Population
- 5-year-old children of the Gen3G cohort (mothers enrolled prenatally 2010–2013, Quebec, Canada) with gut microbiota and DXA data at 5–6.4 years; 43.1% female, 96.1% white, median BMI 52nd percentile140 with metabolite data
- Participants
- 153 children
- Outcome
- Associations of gut microbiota diversity, composition and microbial metabolites with overall mass (OM), fat mass (FM) and lean soft tissue mass (LSTM) by DXA
- Follow-up
- 5-6.4 years of age
Methodological detailsGen3G cohort, 16S rRNA Illumina sequencing, untargeted multiplatform mass spectrometry, adjusted for age, sex, diet and drinking water
- Gen3G cohort
- 16S rRNA Illumina sequencing
- Untargeted multiplatform mass spectrometry
- Adjusted for age, sex, diet and drinking water
Main finding
As reported in the abstract
ASVs associated with overall mass (OM) / fat mass (FM) / lean soft tissue mass (LSTM), of 542 tested
7 / 5 / 4
Observational data: associations, not effects.
Original publication
Gut microbiota and microbial metabolites are associated with body composition in 5‐year‐old children: A cross‐sectional study in the Gen3G cohort. Pediatr Obes. Published 10 March 2025. doi:10.
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