Weight‐loss interventions for adolescents with Down syndrome: a systematic review
Authors' conclusion
Weight-loss interventions can be effective for adolescents with DS and could benefit from increasing duration/intensity to meet the existing weight-loss intervention recommendations. More research on surgery and weight-loss medications is needed.
Study context
- Population
- Adolescents with Down syndrome (DS); databases searched through July 28, 2023
- Participants
- 1,171 adolescents24 studies
- Comparison
- Weight-loss interventions in adolescents with DS
- Outcome
- Change scores for weight or BMI
Methodological detailsPRISMA guidelines, two independent reviewers
- PRISMA guidelines
- Two independent reviewers
Pooled result
As reported in the abstract
Weight or BMI change
- Studies of physical activity interventions
- 11
- Studies of diet interventions
- 1
- Studies of physical activity and diet interventions
- 2
- Studies of multicomponent interventions
- 7
- Studies of laparoscopic sleeve gastrectomy
- 3
- Studies (multicomponent, physical activity or surgery) resulting in weight loss or decreased BMI in adolescents with DS
- 13
Original publication
Weight‐loss interventions for adolescents with Down syndrome: a systematic review. Obesity (Silver Spring). Published 10 March 2025. doi:10.
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