Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011–2018
Authors' conclusion
The separate and combined effects of AO and non-traditional lipid parameters were significantly associated with the risk of developing CMM. Notably, AO may induce CMM by partially mediating the effects of serum lipids in human metabolism. The findings highlighted the importance of joint evaluation of AO and non-traditional lipid parameters for primary prevention of CMM.
Study context
- Population
- Middle-aged and older Chinese adults from the China health and retirement longitudinal study (CHARLS)
- Participants
- 7,597 participants
- Exposure
- Abdominal obesity (AO) and high non-traditional lipid parameters, separately and combined
- Outcome
- Incident cardiometabolic multimorbidity (CMM)
- Follow-up
- 7-year follow-up
Methodological detailsCox proportional hazards models, mediation analysis, restricted cubic splines, subgroup and sensitivity analyses
- Cox proportional hazards models
- Mediation analysis
- Restricted cubic splines
- Subgroup and sensitivity analyses
Main finding
As reported in the abstract
Incident CMM
Newly diagnosed cardiometabolic multimorbidity (CMM)
699
9.20%
Observational data: associations, not effects.
Further findings
Subgroup and sensitivity analyses
- Consistent results across demographic groups and analytical conditions
Mediation by AO
- AO significantly mediated associations between non-traditional lipid parameters and CMM risk
Original publication
Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011–2018. Cardiovasc Diabetol. Published 8 March 2025. doi:10.
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