Associations of atherogenic index of plasma and its related obesity‑composite indices with cardiometabolic multimorbidity across glycemic states: A prospective cohort study of Chinese middle‑aged and older adults
Authors' conclusion
AIP-obesity indices, particularly AIP-CVAI, are independently associated with CMM risk, with consistent effects across glycemic states.
Study context
- Population
- Chinese middle-aged and older adults, China Health and Retirement Longitudinal Study (CHARLS)988 cardiometabolic multimorbidity (CMM) cases
- Participants
- 7,974 participants
- Exposure
- AIP and seven obesity-composite indices across glycemic states
- Outcome
- Cardiometabolic multimorbidity (CMM)
- Follow-up
- 9 years
Main finding
As reported in the abstract
Association of AIP-related indices with CMM · over 9 years
- All indices positively associated with CMM in normal glucose regulation (NGR) and Pre-DM (HRs)
- 1.64-2.03
- Interaction tests non-significant for all indices, consistent associations across glycemic states
- all P for interaction > 0.05
Observational data: associations, not effects.
Further findings
Discrimination of AIP-CVAI for CMM
- AIP-CVAI strongest discrimination (AUC); absolute discriminatory ability modest
- 0.594-0.640
- Incremental gain over traditional risk factors small (integrated discrimination improvement (IDI))
- < 1.5 %
Original publication
Associations of atherogenic index of plasma and its related obesity‑composite indices with cardiometabolic multimorbidity across glycemic states: A prospective cohort study of Chinese middle‑aged and older adults. Diabetes Res Clin Pract. Published 8 September 2026. doi:10.
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