Gut Microbiota Composition and Functionality Are Associated With Rapid Eye Movement (REM) Sleep Duration and Continuous Glucose Levels
An erratum to this article was published (J Clin Endocrinol Metab, 18 Oct 2023 ↗)
Authors' conclusion
Decreased REM sleep duration was independently associated with a worse glucose profile. The associations of species from Christensenellaceae and Enterobacteriaceae families with REM sleep duration and continuous glucose values suggest an integrated picture of metabolic health.
Study context
- Population
- Healthy middle-aged (39.1–54.8 years) volunteers, 60 with obesity, recruited at a tertiary hospital60 with obesity
- Participants
- 118 participants
- Comparison
- Subjects with obesity vs without obesity; associations of REM sleep duration, continuous glucose monitoring (CGM) glucose and gut microbiota
- Outcome
- Associations of REM sleep duration with CGM glucose
Methodological detailsobservational, prospective, real-life
- Observational
- Prospective
- Real-life
Main finding
As reported in the abstract
REM sleep duration independently associated with % TIR3 (β)
β = −.339
P < .001
REM sleep duration independently associated with glucose variability (SD) (β)
β = −.350
P < .001
Observational data: associations, not effects.
Further findings
Gut microbiota
- Christensenellaceae taxa (Firmicutes) positively associated with REM sleep and negatively with CGM levels; Enterobacteriacea bacteria and iron-metabolism functions showed opposite associations
Original publication
Gut Microbiota Composition and Functionality Are Associated With REM Sleep Duration and Continuous Glucose Levels. J Clin Endocrinol Metab. Published 9 May 2023. doi:10.
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