Gut microbiota-based prediction for the transition from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) in a remote island cohort study
Authors' conclusion
Our data suggest that increased proportion of specific GM is linked to the future deterioration of glucose tolerance, thereby serving as a promising predictive marker for type 2 diabetes mellitus.
Study context
- Population
- Individuals with NGT in Kumejima island, Japan; 75 g OGTT at baseline and one year later
- Participants
- 114 individuals
- Exposure
- Baseline gut microbiota (GM) of individuals transitioning NGT to IGT (NTI) vs those maintaining NGT (NRN)
- NTIn = 6
- NRNn = 108reference
- Outcome
- Baseline GM profile predicting development of IGT
- Follow-up
- One year
Main finding
As reported in the abstract
Baseline GM profile
- Proportions of CF231, Corynebacterium, Succinivibrio and Geobacillus significantly elevated in NTI vs NRN (genus level)
- p < 0.005, FDR < 0.1, respectively
Observational data: associations, not effects.
Original publication
Gut microbiota-based prediction for the transition from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) in a remote island cohort study. Diabetes Res Clin Pract. Published 13 June 2024. doi:10.
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