Greater persistence and adherence to basal insulin therapy is associated with lower healthcare utilization and medical costs in patients with type 2 diabetes: a retrospective database analysis
Authors' conclusion
Persistence and adherence to basal insulin was associated with fewer hospitalizations and lower direct medical costs.
Study context
- Population
- US adults with T2D initiating basal insulin, January 1, 2016–December 31, 2018
- Participants
- 64,953 adults
- Exposure
- Persistence/adherence vs non-persistence/non-adherence to basal insulin
- Outcome
- Persistence and adherence to basal insulin
- Follow-up
- 1 year post-initiation
Methodological detailsclaims database (IQVIA PharMetrics Plus), inverse probability of treatment weighting
- Claims database (IQVIA PharMetrics Plus)
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
1 year post-initiation
Demonstrated persistence
56.8%
Demonstrated adherence
41.9%
Observational data: associations, not effects.
Further findings
Hospitalization
- Persistence and adherence significantly less likely to have a hospitalization than non-persistence or non-adherence, respectively
- post-IPTW
Total mean all-cause direct medical costs per patient · second year post-initiation
- Lower with persistence; significantly lower with adherence
Predictors: prior oral and injectable vs only prior oral antidiabetic medication
- Persistence OR
- 1.50 (95% CI, 1.44 to 1.57)
- Adherence OR
- 1.48 (95% CI, 1.42 to 1.55)
- Multivariable logistic regression
Original publication
Greater persistence and adherence to basal insulin therapy is associated with lower healthcare utilization and medical costs in patients with type 2 diabetes: a retrospective database analysis. BMJ Open Diabetes Res Care. Published 4 March 2024. doi:10.
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