Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study
Authors' conclusion
Our results suggest that omentin may influence insulin sensitivity and diabetes risk by changing systemic lipid metabolism, but further mechanistic studies investigating effects of omentin on metabolism of insulin-sensitive tissues are needed.
Study context
- Population
- Participants aged 61–82 years from the population-based KORA F4 Study with serum omentin levels and metabolite concentration profiles available
- Participants
- 1,124 participants
- Outcome
- Associations of serum omentin concentrations with serum metabolites
Methodological detailspopulation-based, five stepwise-adjusted multivariable regression models
- Population-based
- Five stepwise-adjusted multivariable regression models
Main finding
As reported in the abstract
Associations of omentin with serum metabolites
- Omentin significantly associated with multiple metabolites incl. amino acids, acylcarnitines and lipids (eg, sphingomyelins and phosphatidylcholines (PCs))
- Positive associations with several PCs (eg, PC aa C32:1, PC ae C32:2) significant in models 1-4
- Positive associations with hydroxytetradecenoylcarnitine (C14:1-OH) significant in all five models
- Omentin negatively associated with several metabolite ratios (eg, valine-to-PC ae C32:2, serine-to-PC ae C32:2) in most models
Observational data: associations, not effects.
Original publication
Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study. BMJ Open Diabetes Res Care. Published 4 March 2024. doi:10.
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