Good metabolic control is associated with decreased circulating factor VIIa– antithrombin complexes in type 2 diabetes: a cross-sectional study
Authors' conclusion
This is the first study to show that in T2DM higher FVIIa-AT complexes are associated with markers of dyslipidemia and glycemia control, indicating that TF-induced coagulation activation could be suppressed by achieving treatment targets.
Study context
- Population
- T2D patients (mean age 63.8 years, 52.8% men, median HbA1c 6.9 [IQR 6.1–8.2] %) and age- and sex-matched non-diabetic subjects
- Participants
- 108 vs 83
- Exposure
- T2D patients vs non-diabetic controls; top vs bottom quartile of FVIIa-AT complexes within T2D
- T2DMn = 108
- Controlsn = 83reference
- Outcome
- Circulating FVIIa-AT complexes and their determinants in T2D
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
FVIIa-AT complexes
P = 0.30
Observational data: associations, not effects.
Further findings
T2D patients with FVIIa-AT in top vs bottom quartile
- Higher fasting glucose
- + 36.4%
- Higher HbA1c
- + 27.4%
- Higher albumin/creatinine ratio (ACR)
- + 72.8%
- Higher total cholesterol
- + 34.5%
- Higher LDL-C
- + 80%
- Larger prevalence of active smoking and insulin use in top quartile
Prothrombotic state
- No associations of FVIIa-AT complexes with in vitro thrombin generation potential, plasma fibrin clot properties or fibrinolysis variables
Multivariable analysis in T2D
- HbA1c, ACR and total cholesterol remained independently associated with FVIIa-AT complexes
Original publication
Good metabolic control is associated with decreased circulating factor VIIa– antithrombin complexes in type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol. Published 5 November 2024. doi:10.
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