Efficacy and diabetes risk of moderate-intensity statin plus ezetimibe versus high-intensity statin after percutaneous coronary intervention
Main finding · MACCEsResult — go to the resultHazard ratio 0.96 95% CI 0.89–1.03Authors' conclusion
In patients undergoing PCI, moderate-intensity statin plus ezetimibe demonstrated a similar risk of MACCEs but a lower risk of new-onset DM than high-intensity statin. Early combination treatment of moderate-intensity statin and ezetimibe may be a useful and safe lipid-lowering strategy after PCI.
Study context
- Population
- Patients who underwent percutaneous coronary intervention (PCI) from 2012 to 2017, Health Insurance Review and Assessment Service database of South Korea
- Participants
- 45,501 patients7,161 matched pairs
- Exposure
- Moderate-intensity statin plus ezetimibe vs high-intensity statin
- Moderate-intensity statin + ezetimiben = 7,161
- High-intensity statinn = 38,340reference
- Outcome
- Major adverse cardiac cerebrovascular events (MACCEs): composite of all-cause death, revascularization, or ischemic stroke
- Follow-up
- Median 2.7 years
Methodological detailsnationwide claims database, propensity-score matched
- Nationwide claims database
- Propensity-score matched
Main finding
MACCEs · median follow-up 2.7 years
Hazard ratio
0.96
95% CI 0.89–1.03
P = 0.27
Events by group
Moderate-intensity statin + ezetimibevs High-intensity statin
HR 0.96 (95% CI 0.89–1.03); P = 0.27
As reported in the abstract
Observational data: associations, not effects.
Safety
| Outcome | Moderate-intensity statin + ezetimibe | High-intensity statin | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| New-onset DMPropensity-score-matched | 10.7% | 12.5% | 0.84 (0.73–0.97) | P = 0.02 | |
| 0.512Hazard ratio (log scale) |
Original publication
Efficacy and diabetes risk of moderate-intensity statin plus ezetimibe versus high-intensity statin after percutaneous coronary intervention. Cardiovasc Diabetol. Published 5 November 2024. doi:10.
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