Diabetes technology

Glycemic Responses to Graded Exercise Testing in Adolescents Using Automated Insulin Delivery Systems

Diabetes Technol TherPublished Mechanistic study

Authors' conclusion

This study highlights the glycemic safety of performing GXT for adolescents utilizing AID systems.

Study context

Population
Adolescents with T1D using automated insulin delivery (AID) systems
Participants
24 adolescents
Outcome
Plasma glucose during GXT
Follow-up
During GXT
Methodological detailsGXT on a bicycle ergometer until volitional exhaustion; plasma glucose and lactate measured during GXT, sensor glucose monitored in the hours thereafter
  • GXT on a bicycle ergometer until volitional exhaustion; plasma glucose and lactate measured during GXT, sensor glucose monitored in the hours thereafter

Main finding

As reported in the abstract

Plasma glucose stable throughout GXT, overall change

−0.26 mmol/L

−5 mg/dLP = 0.593

Further findings

Sensor glucose after GXT · remaining day and night

Sensor glucose remained stable and within recommended glucose target ranges after GXT

Safety

Hypoglycemic events during GXT
0
Only a few episodes of mild hypoglycemia after GXT

Original publication

Glycemic Responses to Graded Exercise Testing in Adolescents Using Automated Insulin Delivery Systems. Diabetes Technol Ther. Published 5 November 2025. doi:10.1177/15209156251390834

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