Global differences in thyroid autoimmunity and hypothyroidism among children with type 1 diabetes: data from the SWEET database
Authors' conclusion
Future research should clarify the genetic and environmental factors underlying regional disparities in thyroid autoimmunity and disease among children with T1D. Region-specific, evidence-based screening strategies tailored to local prevalence and risk profiles are needed to optimize early detection and clinical outcomes.
Study context
- Population
- Children aged ≤18 years with T1D registered in the SWEET database 2012–2022, with information on thyroid autoimmunity/disease screening
- Participants
- 19,225 children
- Outcome
- Prevalence of thyroid autoimmunity and hypothyroidism
Methodological detailsregistry-based, multinational
- Registry-based
- Multinational
Main finding
As reported in the abstract
Positive thyroid autoimmunity
13.2%
Hypothyroidism
9.9%
Highest adjusted prevalence of thyroid autoimmunity: South America
16.3%
95% CI 13.1–20.1
Highest adjusted prevalence of hypothyroidism: South America
17.1%
95% CI 13.9–21.0
Observational data: associations, not effects.
Further findings
- Age, gender and geographical region were predictive factors for thyroid autoimmunity and hypothyroidism
- Diabetes duration and BMI-Z scores were additional predictive factors for hypothyroidism
Original publication
Global differences in thyroid autoimmunity and hypothyroidism among children with type 1 diabetes: data from the SWEET database. Diabetes Res Clin Pract. Published 17 March 2026. doi:10.
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