Differences in Achieving Stringent Glycemic Targets Among Youth with Type 1 Diabetes: A SWEET Registry Study
Authors' conclusion
Children younger than 6 years and individuals not using glucose-responsive insulin therapy were less likely to meet the recommended glycemic targets.
Study context
- Population
- Youth <21 years with T1D from 23 countries; mean (SD) age 13.7 (4.3) years, diabetes duration 6.3 (4.2) years, 47.8% female
- Participants
- 7,691 participants
- Exposure
- AID vs CGM with insulin pump vs CGM with injections
- Outcome
- Proportion achieving time in tight range target (TITR >50%)
Methodological detailsobservational, international registry (SWEET), mixed-effects fractional logistic and linear regression models
- Observational
- International registry (SWEET)
- Mixed-effects fractional logistic and linear regression models
Main finding
As reported in the abstract
Achieving TITR target (TITR >50%)
P < 0.001
Observational data: associations, not effects.
Further findings
Achieving TIR (>70%) and HbA1c targets by treatment modality
- A similar association was observed for proportions achieving TIR and HbA1c targets
- P < 0.001
Age <6 years: Coefficient of variation (CV) and achieving TITR and TIR targets
- Age <6 years associated with higher CV
- P < 0.001
- Age <6 years associated with lower probability of achieving both TITR and TIR targets vs other age groups
- P < 0.001
TITR vs mean sensor glucose stratified by CV
- Higher TITR with lower CV only at mean glucose below 150-160 mg/dL; above this threshold lower CV associated with lower TITR
Original publication
Differences in Achieving Stringent Glycemic Targets Among Youth with Type 1 Diabetes: A SWEET Registry Study. Diabetes Technol Ther. Published 2 July 2026. doi:10.
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