Gestational diabetes & diabetes in pregnancy
Gestational Diabetes Mellitus Is Associated With Adverse Outcomes in Singleton Pregnancies Conceived via Assisted Reproductive Technology: A Nationwide Inpatient Sample Analysis, 2008–2020
Authors' conclusion
GDM was significantly associated with adverse maternal and fetal outcomes in singleton pregnancies conceived via ART.
Study context
- Population
- Singleton pregnancies conceived via assisted reproductive technology, U.S. Nationwide Inpatient Sample 2008–2020after matching
- Participants
- 9,625 women
- Exposure
- Gestational diabetes mellitus (GDM) vs no GDM
- GDMn = 1,925
- Without GDMn = 7,700reference
- Outcome
- Adverse maternal and fetal outcomes
Methodological detailspropensity-score matched, nationwide database (U.S. Nationwide Inpatient Sample 2008–2020)
- Propensity-score matched
- Nationwide database (U.S. Nationwide Inpatient Sample 2008–2020)
Main finding
As reported in the abstract
GDM vs Without GDMOdds ratio (95% CI)
Preeclampsia
1.24(1.03–1.50)
Placenta previa
1.34(1.08–1.66)
Cesarean delivery
1.30(1.18–1.44)
Induction of labor
1.14(1.02–1.28)
Extended hospital stay
1.48(1.24–1.76)
Preterm birth
1.30(1.10–1.53)
Large for gestational age/fetal macrosomia
1.54(1.26–1.90)
Observational data: associations, not effects.
Further findings
Stratified and interaction analyses
- Generally similar associations across subgroups; formal interaction analyses identified significant interactions for selected outcomes
Original publication
Gestational Diabetes Mellitus Is Associated With Adverse Outcomes in Singleton Pregnancies Conceived via Assisted Reproductive Technology: A Nationwide Inpatient Sample Analysis, 2008–2020. Endocr Pract. Published 6 September 2026. doi:10. 1016/ j. eprac. 2026. 08. 023
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