Gestational diabetes & diabetes in pregnancy
Gestational diabetes mellitus in twin pregnancies versus singleton pregnancies—A retrospective case–control study
Authors' conclusion
We have characterized the effect of twin pregnancy on parameters of glucose metabolism and glycaemic control in GDM in one of the largest studies of twin pregnant women with GDM to date. We conclude that twin pregnant women may have the GDM diagnosis earlier, but diurnal insulin requirements and HbA1c levels are comparable with singleton pregnant women.
Study context
- Population
- Pregnant women with gestational diabetes mellitus (GDM); data from patient filesmatched case–control
- Participants
- 53 vs 212
- Exposure
- Twin vs singleton pregnancies in women with GDM
- Twinn = 53
- Singletonn = 212reference
- Outcome
- Gestational age (GA) at GDM diagnosis
Methodological detailsmatched
- Matched
Main finding
As reported in the abstract
Twin
24 + 5
± 5 + 2 · weeks + days
Singleton
27 + 2
± 5 + 2 · weeks + days
P = 0.002
Observational data: associations, not effects.
Further findings
| Outcome | Twin | Singleton | P value |
|---|---|---|---|
| GA at insulin startInsulin commenced earlier with Twin | 25 + 2 ± 4 + 6 weeks + days | 30 + 1 ± 5 + 0 weeks + days | P = 0.003 |
| HbA1c at diagnosisSignificantly lower with Twin | 34 (5.3) ± 4.8 (2.6) | 35.9 (5.4) ± 5.4 (2.6) | P = 0.03 |
| HbA1c in 2nd trimesterSimilar | mean 33.9 (5.3) ± 4.6 (2.6) | mean 35.7 (5.4) ± 5.3 (2.6) | P = 0.16 |
| HbA1c in 3rd trimesterSimilar | mean 35.1 (5.5) ± 4.2 (2.5) | mean 36.0 (5.4) ± 5.1 (2.6) | P = 0.25 |
- Proportion treated with insulin
- P = 1.0
Proportion treated with insulin
- Proportion of women treated with insulin was similar
Original publication
Gestational diabetes mellitus in twin pregnancies versus singleton pregnancies—A retrospective case–control study. Diabet Med. Published 23 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →