Genetic basis of early onset and progression of type 2 diabetes in South Asians
Authors' conclusion
In conclusion, genetic predisposition to insulin deficiency and lipodystrophy in British Pakistani and British Bangladeshi individuals is associated with earlier onset of T2D, faster progression to complications, insulin dependence and poorer response to medication.
Study context
- Population
- British Pakistani and British Bangladeshi individuals in the Genes & Health study; T2D and Gestational Diabetes Mellitus (GDM)Genes & Health · T2D 11,678 · GDM 1,965
- Participants
- 50,556 participants
- Comparison
- High vs low genetic risk of insulin deficiency and lipodystrophy
- Outcome
- Associations of pPSs with T2D, GDM and age at T2D diagnosis
Methodological detailsmulti-ancestry partitioned polygenic scores
- Multi-ancestry partitioned polygenic scores
Main finding
As reported in the abstract
High vs low genetic risk of both insulin deficiency and lipodystrophy: T2D diagnosed earlier
8.2 years
High vs low genetic risk of both: Body mass index (BMI) lower
3 kg m-2
Further findings
HbA1c response to SGLT2 inhibitors
- Insulin deficiency pPS associated with poorer HbA1c response to SGLT2 inhibitors
Progression to insulin dependence and microvascular complications
- Insulin deficiency and lipodystrophy pPSs associated with faster progression to insulin dependence and microvascular complications
Genetic burden vs white Europeans (UK Biobank)
- South Asians had greater genetic burden from both pPSs than white Europeans in UK Biobank
Original publication
Genetic basis of early onset and progression of type 2 diabetes in South Asians. Nat Med. Published 26 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →