The development and progression of albuminuria in South Asians with type 2 diabetes compared with Western Europeans. Results from the HinDu the Hague diabetes study
Authors' conclusion
South Asians have a higher adjusted risk to develop micro- and macroalbuminuria compared with Western Europeans. When microalbuminuria is present, time to progression from micro- to macroalbuminuria is not different between the two groups.
Study context
- Population
- Adults with T2D treated in a diabetes clinic in 2006 or referred thereafter (HinDu the Hague diabetes study)
- Participants
- 1,269 vs 2,272
- Exposure
- South Asians vs Western Europeans with T2D
- South Asiansn = 1,269
- Western Europeansn = 2,272reference
- Outcome
- Time from diabetes diagnosis until development and progression of albuminuria (no albuminuria, persistent microalbuminuria, macroalbuminuria at end of follow-up)
Methodological detailsclosed cohort, single diabetes clinic, Cox proportional hazard models adjusted for retinopathy, hypertension, smoking and age at diabetes diagnosis
- Closed cohort
- Single diabetes clinic
- Cox proportional hazard models adjusted for retinopathy, hypertension, smoking and age at diabetes diagnosis
Main finding
As reported in the abstract
South Asians vs Western EuropeansHazard ratio (95% CI)
Microalbuminuria; adjusted
1.4(1.2–1.6)
Macroalbuminuria; adjusted
1.2(1.0–1.4)
Observational data: associations, not effects.
Further findings
Mean time to progress from micro- to macroalbuminuria
Mean time to progress from micro- to macroalbuminuria
- Not different between the ethnic groups
Original publication
The development and progression of albuminuria in South Asians with type 2 diabetes compared with Western Europeans. Results from the HinDu the Hague diabetes study. Diabet Med. Published 25 October 2024. doi:10.
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