Natriuretic peptide levels and predicting risk of developing new diabetes mellitus and metabolic syndrome
Main finding · Incident metabolic disease per higher baseline NT-ANPResult — go to the resultOdds ratio 0.65 CI 0.49–0.85Authors' conclusion
In healthy adults aged 45 years or older, higher baseline NT-ANP levels are associated with a lower four-year risk of developing metabolic disease. Serum NT-ANP levels are a sensitive biomarker of future risk of metabolic disease and have screening utility when combined with insulin and aldosterone levels into a composite score.
Study context
- Population
- Healthy adults aged ≥45 years without metabolic disease at enrolment, Olmsted County Heart Function Study (random sample of county residents), enrolled 1997–2000completed follow-up
- Participants
- 715 adults
- Exposure
- Baseline N-terminal atrial natriuretic peptide (NT-ANP) levels and incident metabolic disease
- Outcome
- Incident metabolic disease (metabolic syndrome and T2D)
Main finding
As reported in the abstract
Incident metabolic disease per higher baseline NT-ANP
Odds ratio
0.65
CI 0.49–0.85
P = 0.002
Higher baseline NT-ANP
OR 0.65 (CI 0.49–0.85); P = 0.002
Per higher baseline NT-ANP, as printed
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Incident metabolic disease per higher baseline insulin and aldosteroneHigher baseline insulin | 2.04 (1.57–2.65) | P < 0.001 | |
| Incident metabolic disease per higher baseline insulin and aldosteroneHigher baseline aldosterone | 1.43 (1.14–1.81) | P = 0.002 | |
| 0.20.5125Odds ratio (log scale) |
Prediction of future metabolic disease
- Sensitivity of baseline NT-ANP < 3337 pg/mL
- 96.6%
- Sensitivity of weighted score (NT-ANP, insulin, aldosterone)
- 78.6%
- Specificity of weighted score (NT-ANP, insulin, aldosterone)
- 77.3%
- Cut-points by Youden's index
Original publication
Natriuretic peptide levels and predicting risk of developing new diabetes mellitus and metabolic syndrome. Diabetes Obes Metab. Published 25 November 2024. doi:10.
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