Functional analysis of daily glycemic profiles and excessive fetal growth in pregnant patients with well-controlled type 1 diabetes: Retrospective cohort
Authors' conclusion
Mothers of LGA newborns present significantly worse glycemic control. Our findings may emphasize the need for more rigorous daytime glycemic control.
Study context
- Population
- Pregnant women with T1D treated with sensor-augmented pumps
- Participants
- 102 women
- Exposure
- Mothers of large-for-gestational-age (LGA) vs non-LGA newborns
- LGAn = 28
- Outcome
- Daily glycemic profiles throughout gestation
Methodological detailssingle-center, functional data analysis
- Single-center
- Functional data analysis
Main finding
As reported in the abstract
Glycemic control, LGA vs non-LGA mothers
- Mothers of LGA infants had significantly increased HbA1c and decreased time-in-range (TIR) in the second and third trimesters
- Most significant differences in daily mean glucose occurred between 26 and 32 weeks
- Differences in daytime rather than nocturnal and fasting glucose
Observational data: associations, not effects.
Further findings
HbA1c by trimester (whole cohort) · first, second, third trimester
%
- Median HbA1c first trimester
- 6.23
- Median HbA1c second trimester
- 5.49
- Median HbA1c third trimester
- 5.75
TIR by trimester (whole cohort) · first, second, third trimester
%
- Median TIR first trimester
- 72.4
- Median TIR second trimester
- 72.5
- Median TIR third trimester
- 75.9
Well-controlled T1D (mean HbA1c and TIR criteria) per trimester
- Women meeting criteria
- 59 % up to 77 %
LGA incidence
- Pregnancies complicated by LGA
- 27 % (28/102)
Original publication
Functional analysis of daily glycemic profiles and excessive fetal growth in pregnant patients with well-controlled type 1 diabetes: Retrospective cohort. Diabetes Res Clin Pract. Published 7 January 2024. doi:10.
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