Frequent Use of Premenopausal Progestin in Women With Prior Preeclampsia
Authors' conclusion
Increased use of cyclic progestins and LNG-IUD in premenopausal women with a history of preeclamptic pregnancy can be seen as indirect evidence of earlier onset of ovulatory dysfunction. This may contribute to the elevated risk of endometrial cancer in these women. Our findings may indicate an additional late sequela of preeclamptic pregnancy.
Study context
- Population
- Premenopausal Finnish women with and without prior preeclampsia (1969–1993), followed 1994 to 2019 for oral progestin or LNG-IUD use
- Participants
- 31,688 vs 91,726
- Exposure
- Women with vs without prior preeclampsia
- Prior preeclampsian = 31,688
- Controlsn = 91,726reference
- Outcome
- Cyclic progestin or LNG-IUD use for menstrual cycle abnormalities
- Follow-up
- 1994 to 2019
Main finding
As reported in the abstract
Cyclic progestin use
P < 0.001
Observational data: associations, not effects.
Further findings
Age at initiation of cyclic progestin · younger with prior preeclampsia
P < 0.001
LNG-IUD insertion
P < 0.001
Future menopausal hormone therapy (MHT) use with cyclic progestin or LNG-IUD use
- Cyclic progestin or LNG-IUD use accompanied by significant elevations in future MHT use
- 37% to 90%
Original publication
Frequent Use of Premenopausal Progestin in Women With Prior Preeclampsia. J Clin Endocrinol Metab. Published 8 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →