Association of hyperandrogenaemia with hypertension and cardiovascular events in pre-menopausal women: a prospective population-based cohort study
Authors' conclusion
Women with HA at premenopausal age had an elevated risk of hypertension, and together with BMI, increased risk of CVD events and CVD mortality during the 22-year follow-up. However, because of several study limitations regarding ethnicity and BMI characteristics, a longer follow-up of this cohort and future studies in ethnically diverse populations are needed to verify the results.
Study context
- Population
- Pre-menopausal women; serum T, sex hormone-binding globulin (SHBG) and free androgen index (FAI) measured at age 31; follow-up to age 53
- Participants
- 5,889 women
- Exposure
- Testosterone, SHBG and FAI at age 31 vs blood pressure (BP), hypertension and CVD events
- Outcome
- BP and hypertension (BP ≥ 140/90 mmHg and/or antihypertensive medication) at ages 31 and 46; Cardiovascular disease (CVDs) and combined CVD events by age 53
- Follow-up
- 22-year follow-up
Main finding
As reported in the abstract
BP, hypertension and CVD events
FAI and AP/AMI risk, HR (95% CI), unadjusted
2.02
1.06–3.85
FAI and overall CVD events or mortality, HR (95% CI), unadjusted
1.54
1.02–2.33
Observational data: associations, not effects.
Original publication
Association of hyperandrogenaemia with hypertension and cardiovascular events in pre-menopausal women: a prospective population-based cohort study. Eur J Endocrinol. Published 3 October 2024. doi:10.
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