Fracture risk based on high-resolution peripheral quantitative computed tomography measures does not vary with age in older adults—the bone microarchitecture international consortium prospective cohort study
Authors' conclusion
The stability of the associations between HR-pQCT measures and fracture over a broad age range shows that bone deficits or low volumetric density remain major determinants of fracture risk regardless of age group.
Study context
- Population
- Men and women aged 40–96 with at least one valid baseline high-resolution peripheral quantitative computed tomography (HR-pQCT) scan at distal radius or distal tibia, Bone Microarchitecture International Consortium681 sustained fractures
- Participants
- 6,835 men
- Exposure
- HR-pQCT measures and fracture risk across age quintiles
- Outcome
- Incident fractures and major osteoporotic fractures; association with HR-pQCT measures across age quintiles
- Follow-up
- Censored at first fracture, death, last contact or 8 years after baseline
Methodological detailsinternational consortium
- International consortium
Main finding
As reported in the abstract
Fracture HR per HR-pQCT parameter across age quintiles · median 48.3 months
- After adjustment for confounders, bone parameters at radius and tibia associated with higher fracture risk
- HRs for fracture did not vary significantly across age quintiles for any HR-pQCT parameter at radius or tibia
- Homogeneity across age groups persisted for all fractures and for major osteoporotic fractures; similar regardless of HR-pQCT measure, fracture type or statistical model
- Adjusted for confounders
Observational data: associations, not effects.
Original publication
Fracture risk based on high-resolution peripheral quantitative computed tomography measures does not vary with age in older adults—the bone microarchitecture international consortium prospective cohort study. J Bone Miner Res. Published 3 March 2024. doi:10.
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