Follicle-Stimulating Hormone and Diabetes in Postmenopausal Women: A Systematic Review and Meta-Analysis
Pooled result · FSH levelsResult — go to the resultSMD −0.751 95% CI −1.129 to −.372Authors' conclusion
The available data indicated an indirect association between FSH levels and glucose disturbances among postmenopausal women, notwithstanding heterogeneity among included studies, and the complexity of various influential factors needs to be considered. Further efforts should be made to clarify the underlying mechanisms.
Study context
- Population
- Postmenopausal women; PubMed, Scopus, Web of Sciences, Epistemonikos and Cochrane Library searched up to September 202314 articles
- Participants
- 7,878 women
- Comparison
- Postmenopausal women with DM vs without DM
- Outcome
- Association of circulating FSH levels with DM
Methodological detailsrisk of bias assessed by Newcastle-Ottawa Quality Assessment Scale, Most included studies had low/moderate risk of bias
- Risk of bias assessed by Newcastle-Ottawa Quality Assessment Scale
- Most included studies had low/moderate risk of bias
Pooled result
FSH levels
SMD
−0.751
95% CI −1.129 to −.372
DMvs Without DM
SMD −0.751 (95% CI −1.129 to −.372)
As reported in the abstract
- Pooled effect size for diabetes
- 0.861 (95% CI, 0.740-1.001; I2 = 80.11%)
- Risk of DM, high vs low follicle-stimulating hormone (FSH), HR
- 0.550 (95% CI, 0.356-0.850, I2 = 0)
Further pooled results
Correlation of FSH with glycemic parameters
- FBG, r
- −0.285 (95% CI −0.441 to −0.113); n = 1229
- HOMA-IR, r
- −0.241 (−0.378 to −0.0924); n = 1229
- Insulin, r
- −0.337 (−0.434 to −0.232); n = 959
- Significant inverse correlation
Estradiol and LH levels, DM vs without DM
- No statistically significant differences in estradiol levels
- SMD for LH similar to that reported for FSH
Original publication
Follicle-Stimulating Hormone and Diabetes in Postmenopausal Women: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. Published 30 March 2024. doi:10.
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