Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women
Authors' conclusion
HT effects on standard lipids and LPs are consistent with the literature. HT has similar effect on lipids and LPs in early and late PMW. Novel findings include discordant effects of HT on TG and VLDL particles, which can be explained by increased catabolism of atherogenic remnants of TG-rich lipoproteins. Our findings extend the well-known HT effects on standard lipids and LPs that may contribute to the beneficial effects on atherosclerosis progression in PMW.
Study context
- Population
- Healthy postmenopausal women (PMW), early and late postmenopausal; academic institution240 early, 322 late
- Participants
- 562 participants
- Comparison
- Oral E2 with/without sequential vaginal progesterone (hormone therapy (HT)) vs control, by time-since-menopause
- Primary endpoint
- Standard lipids and 21 LPs quantitated by ion mobility
- Follow-up
- Every 6 months
Methodological detailsstratified by time-since-menopause
- Stratified by time-since-menopause
Primary result
As reported in the abstract
- HT significantly increased total triglycerides (TG), high-density lipoprotein (HDL) cholesterol, small low-density lipoproteins (LDL), large HDL, and TG/C ratio in LDL and HDL
- HT decreased LDL-C, total very low density lipoproteins (VLDL), small VLDL, intermediate-density lipoproteins, large LDL, and LDL peak diameter
- No lipid or LP differences between time-since-menopause strata
Further findings
E2 level and lipids/LPs
- Associations of E2 level with lipids and LPs explained the HT effects
Lipids/LPs and atherosclerosis progression
- Very small LDL and total HDL LPs associated with atherosclerosis progression in late PMW
- Nonsignificant P interaction by time-since-menopause
Original publication
Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women. J Clin Endocrinol Metab. Published 28 March 2024. doi:10.
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