Age-related Curves of Anti-müllerian Hormone (AMH) Using the Gen II, the picoAMH, and the Elecsys Assays in Women With Polycystic Ovary Syndrome
Authors' conclusion
To our knowledge, this is the first study reporting age-specific percentile nomograms of serum AMH levels measured by the Gen II, the picoAMH, and the Elecsys assays in a large population of women with PCOS. These findings may help to interpret AMH levels in patients with PCOS and facilitate the use of AMH as a diagnostic tool across age ranges.
Study context
- Population
- Women aged 20 to 40 years with PCOS
- Participants
- 2,725 women
- Exposure
- AMH measured by Gen II vs picoAMH vs Elecsys assays
- Outcome
- Age-specific percentile curves of AMH for all assays and correlations between AMH, clinical, hormonal and US characteristics
Methodological detailsretrospective
- Retrospective
Main finding
As reported in the abstract
Age-specific percentile nomograms of AMH
- Age-related nomograms for the 5th, 10th, 25th, 50th, 75th, 90th and 95th AMH percentiles calculated with the Lambda-Mu-Sigma method for all assays
- AMH levels significantly different between PCOS phenotypes
- AMH positively correlated with LH, LH/FSH ratio, testosterone, androstenedione, free androgen index, mean follicular number and mean ovarian volume
Observational data: associations, not effects.
Original publication
Age-related Curves of AMH Using the Gen II, the picoAMH, and the Elecsys Assays in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. Published 15 March 2024. doi:10.
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