Examining the causal effect of type 2 diabetes on ischemic heart disease – A longitudinal study with four measurements (1980–2017)
Main finding · IHDResult — go to the resultHazard ratio 1.99 95% CI 1.15–3.44Authors' conclusion
This longitudinal study with four measurements assessed a possible causal association between type 2 diabetes and IHD by applying MSM-Cox with IPTW. Although causality cannot be determined due to the remaining risk of residual bias, the results may help to elucidate a potential causal relationship between type 2 diabetes and IHD. Further causal studies on possible underlying mechanisms are, however, needed.
Study context
- Population
- Random sample of Swedish men and women, Swedish Statistics on Income and Living Conditions (SILC) with nationwide healthcare registers; baseline 1980/81, mean age 36.5 years (range 20–59)369 ischemic heart disease (IHD) cases
- Participants
- 2,014 participants
- Exposure
- T2D vs no T2D
- Outcome
- Ischemic heart disease (IHD)
- Follow-up
- Up to 37 years
Methodological detailsrandom population sample, four measurements every eight years, marginal structural Cox modelling with inverse probability weighting (IPTW), compared with Cox proportional hazard modelling
- Random population sample
- Four measurements every eight years
- Marginal structural Cox modelling with IPTW
- Compared with Cox proportional hazard modelling
Main finding
IHD
Hazard ratio
1.99
95% CI 1.15–3.44
T2Dvs No T2D
HR 1.99 (95% CI 1.15–3.44)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| IHD, conventional Cox proportional hazard modelAdjusted for same variables; non-significant | 1.34 (0.94–1.98) | |
| 0.512Hazard ratio (log scale) |
Original publication
Examining the causal effect of type 2 diabetes on ischemic heart disease – A longitudinal study with four measurements (1980–2017). Diabetes Res Clin Pract. Published 24 February 2023. doi:10.
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