Evaluation of Potential Interference Caused by Endogenous Substances, Drugs, and Variations of Blood Sample Properties and Environmental Conditions, With Blood Glucose Concentrations Measured With a New Strip-Based Blood Glucose Monitoring System
Authors' conclusion
POC BGMS performance was not altered by interfering substances after a rigorous evaluation under a wide range of conditions.
Study context
- Population
- Blood samples tested with the Cobas Pulse strip-based point-of-care blood glucose monitoring system
- Comparison
- Test samples vs control
- Outcome
- Absolute or relative mean bias between test and control
Methodological detailsthree test strip lots, spiked blood samples, extreme environmental conditions, Studies performed using three lots of Cobas glucose test strips
- Three test strip lots
- Spiked blood samples
- Extreme environmental conditions
- Studies performed using three lots of Cobas glucose test strips
Main finding
As reported in the abstract
Mean absolute or relative bias vs control
- Mean bias did not exceed ±10 mg/dL or ±10% for any endogenous substance or drug, any hematocrit/glucose combination tested, or altitudes up to 4300 m, with any of the 3 strip lots
- Varying oxygen concentrations (partial pressure) did not affect glucose measurements
- All interference results were within the specified accuracy limits
- Contamination with skin disinfectants, extreme ascorbic acid levels or hematocrit outside the claimed range did not cause wrong test results
Original publication
Evaluation of Potential Interference Caused by Endogenous Substances, Drugs, and Variations of Blood Sample Properties and Environmental Conditions, With Blood Glucose Concentrations Measured With a New Strip-Based Blood Glucose Monitoring System. J Diabetes Sci Technol. Published 31 May 2025. doi:10.
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