Evaluation of glycated albumin levels in tears and saliva as a marker in patients with diabetes mellitus
Authors' conclusion
GA levels in tear and saliva specimens, as diabetes-related biomarkers, can be measured non-invasively. Since this measurement can be performed noninvasively and not as frequently as compared with the more invasive finger prick method, it is expected to reduce the burden on people with diabetes in terms of both the invasiveness and cost-effectiveness. In the future, we would like to verify the effect of regular GA measurement on the glycemic control while considering the clinical cost-effectiveness.
Study context
- Population
- People with DM; tear and saliva samples
- Participants
- 48 people
- Outcome
- Correlation of GA levels in tears and saliva (LC-MS/MS) with blood GA levels
Methodological detailsGlycated albumin (GA) measured by LC-MS/MS
- GA measured by LC-MS/MS
Main finding
As reported in the abstract
Correlation of tear and saliva GA with blood GA
- GA levels in both tear and saliva significantly correlated with blood GA
- P < 0.001
- Correlations maintained after adjustment for BMI, age and nephropathy stage (multiple regression)
- P < 0.001
Observational data: associations, not effects.
Original publication
Evaluation of glycated albumin levels in tears and saliva as a marker in patients with diabetes mellitus. Diabetes Res Clin Pract. Published 22 March 2023. doi:10.
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