Evaluation of Five Novel Intervention Components in Online Obesity Treatment: Outcomes of a Randomized Factorial Experiment
Authors' conclusion
This study identified a combination of intervention components that may improve weight loss outcomes compared to the established online treatment program.
Study context
- Population
- Adults with obesity in an online behavioral obesity treatment program; 83% female; mean age 53.5 ± 11.7 years; mean BMI 35.0 ± 6.1 kg/m²; 23% racial and/or ethnic minorityrandomized
- Participants
- 384 adults
- Comparison
- Established online obesity treatment program with randomization to zero to five novel intervention components
- Primary endpoint
- Weight loss
- Follow-up
- 12 months
Methodological detailsfactorial experiment, multiphase optimization strategy framework
- Factorial experiment
- Multiphase optimization strategy framework
Primary result
As reported in the abstract
12-month weight loss
- No intervention component independently improved weight loss
- p values > 0.199
- Interaction terms suggest the combination of interactive video feedback, skills for dysregulated eating, and social support with friendly competition improved weight loss
- p values < 0.01
Further findings
Mediation analysis
- Social support and dysregulated eating interventions influenced weight loss through improvements in social support for physical activity and dietary quality
Original publication
Evaluation of Five Novel Intervention Components in Online Obesity Treatment: Outcomes of a Randomized Factorial Experiment. Obesity (Silver Spring). Published 18 September 2025. doi:10.
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