Obesity

Evaluating the “2cm2kg” Target in Japan's Specific Health Checkups: Evidence From the Panasonic Cohort Study 30

Obesity (Silver Spring)Published Cohort study

Authors' conclusion

Reductions ≥ 2cm2kg were associated with metabolic improvements in Specific Health Checkups and Guidance-eligible individuals.

Study context

Population
Adults ≥40 years undergoing health checkups in 2020, Panasonic cohort study, Japan
Participants
30,240 adults
Exposure
Achievement of ≥2 cm waist circumference (WC) and ≥2 kg body weight (BW) reduction vs non-achievement
Outcome
Validity of the 2cm2kg target: changes in anthropometrics, glucose, BP, lipids and liver function
Follow-up
1 year

Main finding

As reported in the abstract

Metabolic indicators
Significantly associated with improvements in TG, LDL-C, blood pressure (BP), liver function and HDL-C
all p < 0.0001

Observational data: associations, not effects.

Further findings

Cutoff values predicting metabolic improvements (ROC)

WC cutoff
−1 to −2 cm
BW cutoff
−1 to −2 kg
Spline analyses showed monotonic improvements with greater WC and BW reductions

Original publication

Evaluating the “2cm2kg” Target in Japan's Specific Health Checkups: Evidence From the Panasonic Cohort Study 30. Obesity (Silver Spring). Published 4 April 2026. doi:10.1002/oby.70186

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