Epicardial Adipose Tissue Is Associated With Geometry Alteration and Diastolic Dysfunction in Prediabetic Cardiomyopathy
Authors' conclusion
Elevated EAT was observed in patients with prediabetes and is associated with adverse alterations in cardiac structure and diastolic function, potentially serving as an underlying mechanism for the early onset of diabetic cardiomyopathy.
Study context
- Population
- Individuals categorized by glucose tolerance status, assessed by echocardiography and cardiac magnetic resonance imaging (CMRI)
- Participants
- 370 individuals
- Exposure
- Normal glucose tolerance vs prediabetes vs diabetes
- Normal glucose tolerancen = 209reference
- Prediabetesn = 82
- Diabetesn = 79
- Outcome
- EAT
Main finding
As reported in the abstract
P = 0.001
Observational data: associations, not effects.
Further findings
Left atrial volume index — Normal glucose tolerance vs Prediabetes vs Diabetes
P < 0.001
LV peak filling rate — Normal glucose tolerance vs Prediabetes vs Diabetes
P < 0.001
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Heart geometry alteration (adjusted)Prediabetesvs Normal glucose toleranceAfter adjusting for covariates | 1.22 (1.02–1.83) | P = 0.012 | |
| Heart geometry alteration (adjusted)Diabetesvs Normal glucose toleranceAfter adjusting for covariates | 1.42 (1.11–1.97) | P = 0.032 | |
| Diastolic dysfunction (adjusted)Prediabetesvs Normal glucose toleranceAfter adjusting for covariates | 1.70 (0.79–3.68) | P = 0.135 | |
| Diastolic dysfunction (adjusted)Diabetesvs Normal glucose toleranceAfter adjusting for covariates | 2.56 (1.03–5.40) | P = 0.034 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Normal glucose tolerance | Prediabetes | Diabetes | P value |
|---|---|---|---|---|
| E/e' ratioNormal glucose tolerance vs Prediabetes vs Diabetes | 7.9 ± 0.51 | 8.5 ± 0.64 | 10.0 ± 0.93 | P = 0.010 |
Original publication
Epicardial Adipose Tissue Is Associated With Geometry Alteration and Diastolic Dysfunction in Prediabetic Cardiomyopathy. J Clin Endocrinol Metab. Published 12 June 2024. doi:10.
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