Endocrine regulation of cardiac repolarization: early QTc shortening after testosterone in healthy AFAB adults
Authors' conclusion
These findings demonstrate rapid ventricular repolarization remodeling after testosterone initiation, with a magnitude comparable to the sex-based QTc gap.
Study context
- Population
- Healthy adults assigned female at birth initiating gender-affirming hormone therapy with daily transdermal testosterone gel
- Participants
- 10 adults
- Exposure
- 3 months of transdermal testosterone vs baseline
- Outcome
- ECG repolarization, baseline to 3 months
- Follow-up
- 3 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
QTc change, Bazett
−32 ms
P = .002
QTc change, Fridericia
−14 ms
P = .010
Observational data: associations, not effects.
Original publication
Endocrine regulation of cardiac repolarization: early QTc shortening after testosterone in healthy AFAB adults. Eur J Endocrinol. Published 1 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →