Gestational diabetes & diabetes in pregnancy
Elevated Serum Uric Acid Is Associated With Gestational Diabetes Mellitus: An Observational Cohort Study
Authors' conclusion
Elevated uric acid levels before 24 weeks of gestation are associated with subsequent GDM; the best time to test for uric acid is before 18 weeks of gestation. Pregnant women with low and intermediate risk for GDM development may benefit more from serum uric acid measurements before 18 weeks of gestation.
Study context
- Population
- Singleton pregnant women, February 2018 to June 2022
- Participants
- 23,843 women
- Exposure
- Serum uric acid categories before 24 weeks of gestation
- Outcome
- GDM diagnosed at 24 to 28 weeks of gestation
- Follow-up
- 24 to 28 weeks of gestation
Main finding
As reported in the abstract
GDM
Each group vs uric acid <240 µmol/LAdjusted relative risk (95% CI)
Uric acid 240–300 µmol/L
1.43(1.29–1.56)
Uric acid >300 µmol/L
1.82(1.55–2.15)
- Diagnosed with gestational diabetes mellitus (GDM) (overall cohort)
- 3204 (13.44%)
Observational data: associations, not effects.
Secondary outcomes
- Uric acid had a similar relationship with GDM A2, preterm birth, and GDM combined with pre-eclampsia
Original publication
Elevated Serum Uric Acid Is Associated With Gestational Diabetes Mellitus: An Observational Cohort Study. J Clin Endocrinol Metab. Published 2 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →