Elevated levels of plasma inactive stromal cell derived factor-1α predict poor long-term outcomes in diabetic patients following percutaneous coronary intervention
Authors' conclusion
The study results indicate that elevated levels of plasma inactive SDF-1α might be a useful indicator of poor long-term outcomes in diabetic patients following PCI.
Study context
- Population
- Consecutive patients with diabetes mellitus (DM) who underwent first percutaneous coronary intervention (PCI) between 2008 and 2018, Juntendo University Hospital, Tokyo, Japan
- Participants
- 849 patients
- Exposure
- Plasma inactive, total and active SDF-1α levels as predictors of outcomes
- Outcome
- All-cause death
Methodological detailssingle-centre, consecutive patients, analysis of a prospective registry database, Total and active SDF-1α measured by ELISA; inactive isoform calculated as total minus active
- Single-centre
- Consecutive patients
- Analysis of a prospective registry database
- Total and active SDF-1α measured by ELISA; inactive isoform calculated as total minus active
Main finding
As reported in the abstract
All-cause death per 1 higher log-transformed inactive SDF-1α
HR (multivariate Cox) per 1 higher log-transformed inactive SDF-1α
2.64
95% CI 1.28–5.34p = 0.008
Observational data: associations, not effects.
Secondary outcomes
3P-MACE (CV death, non-fatal MI, ischemic stroke) per 1 higher log-transformed inactive SDF-1α
- HR (multivariate Cox) per 1 higher log-transformed inactive SDF-1α
- 2.51 (95% CI 1.12-5.46; p = 0.02)
- Unadjusted Kaplan-Meier: increased risk of 3P-MACE with elevated inactive SDF-1α
Predictive performance (C-statistic), inactive vs total SDF-1α
- All-cause death: inactive vs total SDF-1α
- 0.631 vs 0.554
- 3P-MACE: inactive vs total SDF-1α
- 0.623 vs 0.524
Original publication
Elevated levels of plasma inactive stromal cell derived factor-1α predict poor long-term outcomes in diabetic patients following percutaneous coronary intervention. Cardiovasc Diabetol. Published 30 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →