Efficacy and safety of switching to insulin glargine 300 U/mL in people with type 2 diabetes uncontrolled on basal insulin in China: A post hoc subpopulation analysis of the INITIATION study
Authors' conclusion
Gla-300 improved glycaemic control with a relatively low hypoglycaemia risk and minimal weight gain in Chinese people with T2D uncontrolled on previous BI.
Study context
- Population
- Adults with T2D uncontrolled (HbA1c 7.5%-11.0% [58–97 mmol/mol]) on previous basal insulin, China; 232 switched from Gla-100, 55 from insulin degludec (IDeg)
- Participants
- 302 adults
- Comparison
- Switching to Gla-300 from another basal insulin
- Gla-300n = 302
- Primary endpoint
- HbA1c change
- Follow-up
- Week 24
Methodological detailsinterventional, phase IV
- Interventional
- Phase IV
Primary result
As reported in the abstract
HbA1c change from baseline
| Group | Value | Change in mmol/mol | P |
|---|---|---|---|
| Gla-300 | mean −0.87 (SE 0.06%) % | −9.5 ± 0.7 mmol/mol | p <0.001 |
Gla-300
Valuemean −0.87 (SE 0.06%) %
Change in mmol/mol−9.5 ± 0.7 mmol/mol
Pp <0.001
Further findings
FPG change from baseline · week 24
- Significant reduction in FPG, LSM change (mmol/L)
- −1.13
- P
- P < 0.001
Fasting SMBG change from baseline · week 24
- Significant reduction in fasting SMBG, LSM change (mmol/L)
- −1.36
- P
- P < 0.001
Mean daily basal insulin dose · baseline to week 24
U
- Mean daily basal insulin (BI) dose at baseline
- 18.86 (0.27 U/kg)
- Mean daily BI dose at week 24
- 28.83 (0.41 U/kg)
Body weight change
- Minimal body weight change was documented
Safety
Hypoglycaemia incidence · 24-week treatment period
- All hypoglycaemia
- 43.8%
- Nocturnal hypoglycaemia
- 15.1%
- Severe hypoglycaemia
- 0.7%
Body weight
- Minimal body weight change was documented
Original publication
Efficacy and safety of switching to insulin glargine 300 U/mL in people with type 2 diabetes uncontrolled on basal insulin in China: A post hoc subpopulation analysis of the INITIATION study. Diabetes Obes Metab. Published 18 December 2024. doi:10.
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