Efficacy and safety of automated insulin delivery system in very young children with type 1 diabetes: A systematic review and meta‐analysis of randomized controlled trials
Pooled result · TIR 70-180 mg/dLResult — go to the resultMD +9.29 % 95% CI 7.27–11.30Authors' conclusion
AID systems may outperform SC in improving short-term glycaemic control (TIR, HbA1c, TAR) in very young children with T1D, without increasing time in hypoglycaemia, insulin dose, or risk of SH and DKA.
Study context
- Population
- Children with T1D under 7 years old; mean age 4.70 years, mean T1D duration 1.96 years; study duration 8 to 16 weeks
- Participants
- 292 children4 randomized controlled trials (RCTs)
- Comparison
- Automated insulin delivery (AID) systems vs standard care
- Outcome
- Percentage of TIR 70-180 mg/dL derived from continuous glucose monitoring (CGM)
Methodological detailsPubMed, Embase, Scopus and Web of Science searched until 10 October 2025
- PubMed, Embase, Scopus and Web of Science searched until 10 October 2025
Pooled result
TIR 70-180 mg/dL
MD
+9.29 %
95% CI 7.27–11.30
P < 0.001
As reported in the abstract
Further pooled results
| Outcome | MD (mmol/mol) (95% CI) | P value | |
|---|---|---|---|
| HbA1cAIDvs SCI2 = 82% | −4 (−6 to −2) | P < 0.001 | |
| −10−505Difference, mmol/mol (linear scale) |
| Outcome | MD (%) (95% CI) | P value | |
|---|---|---|---|
| HbA1cAIDvs SCI2 = 82% | −0.39 (−0.57 to −0.21) | P < 0.001 | |
| −1−0.500.5Difference, % (linear scale) |
Time-above-range (TAR) (>180 mg/dL; >250 mg/dL) and mean blood glucose
- Favourable decrease in TAR (>180 mg/dL; >250 mg/dL) and mean blood glucose with AID over SC
- all p < 0.05
Insulin dose
- No significant difference between AID and SC in insulin dose
- all p > 0.05
Safety
- No significant differences between AID and SC in time in hypoglycaemia and risk of severe hypoglycaemia (SH) and diabetic ketoacidosis (DKA)
- all p > 0.05
Original publication
Efficacy and safety of automated insulin delivery system in very young children with type 1 diabetes: A systematic review and meta‐analysis of randomized controlled trials. Diabet Med. Published 10 May 2026. doi:10.
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