Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8‐Week Crossover Study
Authors' conclusion
Premeal immediate-release metformin reduces postmeal glycemic excursions more effectively than postmeal administration.
Study context
- Population
- Women with T2D on metformin monotherapy (age 49.5 ± 9.7 years, BMI 29.1 ± 5.0 kg/m², HbA1c 7.0% ± 0.3%)20 analysed
- Participants
- 22 women
- Comparison
- Premeal vs postmeal immediate-release metformin
- Primary endpoint
- Postmeal glucose responses to a standardized mixed-meal
Methodological details4 weeks per regimen
- 4 weeks per regimen
Primary result
As reported in the abstract
Glucose iAUC after standardized mixed-meal (mg/dL.h)
- Glucose incremental area under curve (iAUC) significantly lower with premeal at 0-1 h and 0-2 h
- Premeal vs Postmeal: P = 0.034
- Premeal vs Postmeal: P = 0.035
Secondary outcomes
CGM glucose iAUC 0-1 h
P < 0.001
CGM glucose iAUC 0-2 h
P < 0.001
CGM glucose iAUC 0-3 h
P = 0.008
Fructosamine and insulin
- Fructosamine and insulin levels did not differ between groups
Original publication
Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8‐Week Crossover Study. Diabetes Obes Metab. Published 17 April 2026. doi:10.
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