Effects of short‐term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial
Authors' conclusion
The implemented exercise protocol did not reduce IHTG, but it led to modest improvement in markers of cardiometabolic health.
Study context
- Population
- Adolescents aged 13–18 y with obesity (BMI 36.7 ± 5.8 kg/m²) at risk for MASLD based on obesity and elevated Fibroscan controlled attenuation parameter (CAP) scores
- Participants
- 40 adolescents
- Comparison
- 4-week supervised high-intensity interval training (HIIT) vs observation
- HIITn = 34
- Controln = 6reference
- Primary endpoint
- IHTG (%) by liver magnetic resonance imaging proton-density fat-fraction (MRI-PDFF)
- Follow-up
- 4 weeks
Methodological detailssupervised exercise
- Supervised exercise
Primary result
As reported in the abstract
IHTG, within-group change with HIIT
| Group | Value | Baseline IHTG | Δ |
|---|---|---|---|
| HIIT | 5.26 % | 5.26% | −0.31 percentage points |
HIIT
Value5.26 %
Baseline IHTG5.26%
Δ−0.31 percentage points
- HIIT had no impact on IHTG
- Δ −0.31 percentage points (95% CI −0.77 to 0.15; p = 0.179)
Further findings
MASLD by MRI-PDFF (IHTG ≥ 5%) at baseline
2-h glucose concentration, within-group change with HIIT · 4 weeks
- Decrease with HIIT from baseline 116 mg/dL
- −11 mg/dL (95% CI −17.6 to −5.5; p < 0.001)
IHTG in participants with MASLD (n = 17), within-group change with HIIT · 4 weeks
- Decrease with HIIT from baseline 8.81%
- −1.05 percentage points (95% CI −2.08 to −0.01; p = 0.048)
Cardiorespiratory fitness (CRF) · 4 weeks
- HIIT had no impact on CRF
Original publication
Effects of short‐term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial. Obesity (Silver Spring). Published 20 September 2023. doi:10.
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