Effects of radioactive iodine on clonal hematopoiesis in patients with thyroid cancer: A prospective study
Authors' conclusion
There was no increase in CH in patients treated with RAI over a 2-year follow-up period. Larger studies with longer follow-up periods are needed to investigate the association between RAI and clonal dynamics. The presence of CH is associated with worse structural progression in both BRAFV600E-mutant and wild-type thyroid cancers.
Study context
- Population
- Patients with thyroid carcinoma exposed to radioactive iodine (RAI) and age-matched unexposed controls
- Participants
- 20 vs 20
- Exposure
- RAI exposure vs no RAI exposure
- RAIn = 20
- Controlsn = 20reference
- Outcome
- Effect of RAI on clonal hematopoiesis (CH) status
- Follow-up
- Baseline, 6, 12, 18 and 24 months
Methodological detailsage-matched unexposed controls
- Age-matched unexposed controls
Main finding
As reported in the abstract
CH (VAF 2%)
P = 0.11
Observational data: associations, not effects.
Further findings
CH VAF increase · no significant difference
P = 0.2
| Outcome | P value |
|---|---|
| CH by age (VAF 2%)Older (55-80 years) vs Younger (20-40 years) | P = 0.11 |
- Clonal hematopoiesis (CH) by age (variant allelic fraction (VAF) 2%): Older (55-80 years) 6/20 events
- CH by age (VAF 2%): Younger (20-40 years) 2/20 events
CH associations
- CH significantly associated with somatic BRAFV600E mutations and worse progression-free survival, overall and among BRAFV600E-mutant tumors
Original publication
Effects of radioactive iodine on clonal hematopoiesis in patients with thyroid cancer: A prospective study. Clin Endocrinol (Oxf). Published 23 April 2023. doi:10.
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