Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis
Authors' conclusion
Our meta-analysis suggested that probiotics may delay the progression of liver function injury, improve lipid metabolism, reduce weight, and reduce food intake, although the effects on other indicators were insignificant. Probiotics may be helpful for patients undergoing bariatric surgery. The review was
Study context
- Population
- Patients with morbid obesity undergoing bariatric surgery11 RCTs and controlled clinical trials
- Comparison
- Probiotics vs protocol groups after bariatric surgery
- Outcome
- Effects of probiotics on clinical indicators
Methodological detailsrandom effect model when severe heterogeneity, Databases searched from inception to April 4, 2023; no language restrictions
- Random effect model when severe heterogeneity
- Databases searched from inception to April 4, 2023; no language restrictions
Pooled result
As reported in the abstract
Probiotics vs ProtocolMD, U/L (95% CI)P value
Aspartate amino transferase
−4.32(−7.10 to −1.53)
P = 0.002Probiotics vs ProtocolMD, mg/dL (95% CI)P value
TG
−20.16(−34.51 to −5.82)
P = 0.006Probiotics vs ProtocolMD, kg (95% CI)P value
Weight
−1.99(−3.97 to −0.01)
P = 0.05Probiotics vs ProtocolMD, pg/dL (95% CI)P value
Vitamin B12
2.24(−0.02 to 4.51)
P = 0.05Probiotics vs ProtocolMD, kcal (95% CI)P value
Dietary energy
−151.03(−215.68 to −86.37)
P < 0.00001Probiotics vs ProtocolMD, g/day (95% CI)P value
Dietary protein
−4.48(−8.76 to −0.20)
P = 0.04Dietary carbohydrate
−34.25(−44.87 to −23.62)
P < 0.00001Dietary fiber
−2.17(−3.21 to −1.14)
P < 0.0001Safety
- No severe side effects related to probiotics
Original publication
Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis. Int J Obes (Lond). Published 6 September 2023. doi:10.
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