Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men
Authors' conclusion
The beneficial effects of GLP-1 on whole-body glycemic control are evident with insulin clamped at fed-state levels. GLP-1 further enhances the effects of insulin on whole-body glucose uptake in older men, underlining its role as a therapeutic target. The effects of GLP-1 in enhancing microvascular flow likely also affects other glucose-regulatory organs, reflected by greater whole-body glucose uptake.
Study context
- Population
- Older men (71 ± 1 years)crossover
- Participants
- 8 men
- Comparison
- Femoral arterial GLP-1 infusion vs feeding alone during fed-state clamps
Methodological detailsfed-state insulin and glucose clamps
- Fed-state insulin and glucose clamps
Primary result
As reported in the abstract
Skeletal muscle microvascular blood flow (fold-change from basal)
GLP-1
5.0
± 2.1 · fold-change from basal
Feeding alone
1.9
± 0.7 · fold-change from basal
P = 0.008
Further findings
Whole-body glucose uptake (AUC) · 180 minutes
P = 0.02
Original publication
Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men. J Clin Endocrinol Metab. Published 19 October 2022. doi:10.
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