Effects of Exercise on Bone Marrow Adipose Tissue in Children With Overweight/Obesity: Role of Liver Fat
Authors' conclusion
The addition of exercise to a family-based lifestyle program designed to reduce cardiometabolic risk improves bone health by reducing LS-BMFF in children with overweight or obesity. This beneficial effect on bone marrow appears to be mediated by reductions in liver fat.
Study context
- Population
- Children with overweight/obesity, primary care centers in Vitoria-Gasteiz, Spain
- Participants
- 116 children
- Comparison
- Family-based lifestyle program plus supervised exercise vs lifestyle program alone
- Exercisen = 59
- Controln = 57reference
- Primary endpoint
- Change in lumbar spine bone marrow fat fraction (BMFF) (LS-BMFF) estimated by MRI
- Follow-up
- Baseline to 22 weeks
Methodological detailsancillary analysis, 2-arm, parallel, primary care centers
- Ancillary analysis
- 2-arm
- Parallel
- Primary care centers
Primary result
As reported in the abstract
Change in LS-BMFF · 22 weeks
Only the children in the Exercise group had a reduction in LS-BMFF; effect size (Cohen d)
−0.42
CI, −0.86 to −0.01
Further findings
| Outcome | Mean weight loss difference (kg) |
|---|---|
| Weight lossIn favor of Exercise | 1.4 ± 0.5 |
Mediation of LS-BMFF reduction by change in % hepatic fat
- Share of LS-BMFF reductions mediated by changes in % hepatic fat
- 40.9%
- Indirect effect β
- −0.104 (95% CI, −0.213 to −0.019)
- Effect of hepatic fat changes on LS-BMFF independent of weight loss
Original publication
Effects of Exercise on Bone Marrow Adipose Tissue in Children With Overweight/Obesity: Role of Liver Fat. J Clin Endocrinol Metab. Published 7 August 2024. doi:10.
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